What's the difference between Parle and Parlez?

I know parle is pronounced (parl) and Parlez (parle). I heard parle is used for one person and parlez is used for multiple. When you're saying "est-ce que vous parlez francais?" what if you're only talking to one person?

Hello Kelsey.
Vous can be applied to one person (same as with the pronoun "tu" but formal or polite). It can be used when you talk to a person you don't know.

Regards,
Alex Moreno